Peer-reviewed veterinary case report
How to diagnose aspergillosis in birds?
By Cray, Carolyn et al.·Published in Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2009·University of Miami Miller School of Medicine, United States·View original on PubMed →
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Original publication title: Application of galactomannan analysis and protein electrophoresis in the diagnosis of aspergillosis in avian species.
- Species:
- bird
Plain-English summary
Researchers looked into how well two tests could help diagnose aspergillosis, a fungal infection, in birds. They found that birds with the infection had much higher levels of a substance called galactomannan compared to healthy birds. When using a specific cutoff level, the galactomannan test was fairly accurate, identifying about 67% of infected birds correctly. They also checked the birds' blood proteins and found that those with the infection had different protein patterns. Together, these tests showed promise for diagnosing aspergillosis in birds, but they are not perfect, as the combination of both tests identified a high percentage of infected birds but also had a lower accuracy for healthy ones.
Abstract
Previous studies support the possible application of galactomannan, a major antigen of Aspergillus sp., to aspergillosis diagnosis in avian and other animal species. An assay is commercially available for use with human serum and bronchoalveolar lavage fluid samples. In the current study, galactomannan results from plasma samples were compared between birds with histologically confirmed aspergillosis and those that were clinically normal presumptively non-Aspergillus infected birds per submitting practitioners' responses to a questionnaire. It was observed that infected birds demonstrated a 2.6-fold increase in galactomannan over birds without evidence of aspergillosis. With the use of a galactomannan index of 0.5 as a cutoff, the sensitivity and specificity of the test were found to be 67% and 73%, respectively. In addition, plasma samples were analyzed for abnormalities in protein electrophoretic patterns. Infected birds had a higher incidence of increased beta and/or gamma globulin concentrations. Test sensitivity and specificity were 73% and 70%, respectively. If the 2 tests were used as a panel, then the sensitivity was 89% and specificity was 48%. These data indicate that both galactomannan and protein electrophoresis may be valuable tools in the diagnosis of avian aspergillosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19368241/