Application of HN-FeONanoparticles for Prostate Cancer Magnetic Resonance Imaging in an Animal Model.

Abstract

This paper presents the efficacy of a contrast agent based on HN-FeOnanoparticles for the detection of prostate cancer in an animal model using a preclinical 9.4 T MRI system. The relaxivities rand rof the nanoparticles were 6.31 mMsand 8.33 mMs, respectively. Nanoparticles injected in a concentration of 2 mg Fe/mL decreased the tumor-relative Trelaxation across all animals from 100 to 76 &#xb1; 26, 85 &#xb1; 27, 89 &#xb1; 20, and 97 &#xb1; 16 12 min 1 h, 2 h, and 24 h post injection, respectively. The corresponding Tdecrease in muscle tissues was 90 &#xb1; 20, 94 &#xb1; 23, 99 &#xb1; 12, and 99 &#xb1; 14. The relative Tchanges in the tumor were 82 &#xb1; 17, 89 &#xb1; 19, 97 &#xb1; 14, and 99 &#xb1; 8 12 min, 1 h, 2 h, and 24 h post injection, respectively, while, for muscle tissues, these values were 95 &#xb1; 11, 95 &#xb1; 8, 97 &#xb1; 6, and 95 &#xb1; 10 at the corresponding time points. The differences in the relative Tand Twere only significant 12 min after injection (< 0.05), although a decrease was visible at each time point, but it was statistically insignificant (> 0.05). The results showed the potential application of HN-FeOnanoparticles as contrast agents for enhanced prostate cancer MRI.