Peer-reviewed veterinary case report
Collagen-coated pig bone graft tested for dog bone healing
By Jo, Hyun Min et al.·Published in Frontiers in veterinary science·2024·Department of Veterinary Surgery, South Korea·View original on PubMed →
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Original publication title: Application of modified porcine xenograft by collagen coating in the veterinary field: pre-clinical and clinical evaluations.
- Species:
- pig
Plain-English summary
A dog with a bone fracture underwent treatment using a special bone graft made from pig tissue that was coated with collagen to help with healing. The graft was tested in a lab and showed good results, leading to its use in two orthopedic cases and one dental case in dogs. In both orthopedic cases, the fractures healed successfully, and the dental case saw effective bone regeneration without any complications. This innovative treatment could become a common option for helping dogs recover from bone injuries.
People also search for: dog bone fracture treatment · collagen bone graft for dogs · dog dental bone regeneration
Abstract
INTRODUCTION: This study aimed to identify a collagen-coating method that does not affect the physicochemical properties of bone graft material. Based on this, we developed a collagen-coated porcine xenograft and applied it to dogs to validate its effectiveness. METHODS: Xenografts and collagen were derived from porcine, and the collagen coating was performed through N-ethyl-N'-(3- (dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) activation. The physicochemical characteristics of the developed bone graft material were verified through field emission scanning electron microscope (FE-SEM), brunauer emmett teller (BET), attenuated total reflectance-fourier transform infrared (ATR-FTIR), and water absorption test. Subsequently, the biocompatibility and bone healing effects were assessed using a rat calvarial defect model. RESULTS: The physicochemical test results confirmed that collagen coating increased bone graft materials' surface roughness and fluid absorption but did not affect their porous structure.evaluations revealed that collagen coating had no adverse impact on the bone healing effect of bone graft materials. After confirming the biocompatibility and effectiveness, we applied the bone graft materials in two orthopedic cases and one dental case. Notably, successful fracture healing was observed in both orthopedic cases. In the dental case, successful bone regeneration was achieved without any loss of alveolar bone. DISCUSSION: This study demonstrated that porcine bone graft material promotes bone healing in dogs with its hemostatic and cohesive effects resulting from the collagen coating. Bone graft materials with enhanced biocompatibility through collagen coating are expected to be widely used in veterinary clinical practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38566748/