Peer-reviewed veterinary case report
Detecting Babesia canis infection in dogs using MALDI-TOF mass
By Adaszek, Łukasz et al.·Published in Parasitology research·2014·Department of Epizootiology and Infectious Diseases·View original on PubMed →
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Original publication title: Application the mass spectrometry MALDI-TOF technique for detection of Babesia canis canis infection in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with symptoms of babesiosis, caused by the Babesia canis canis parasite, were tested using a new mass spectrometry technique to see if it could quickly identify the infection. The test found a specific protein in the blood of infected dogs that healthy dogs did not have, suggesting it could be a marker for the disease. This method showed high accuracy and could be used in veterinary labs to help diagnose this serious infection in dogs.
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Abstract
The aim of this study was to use rapid mass spectrometry (MS)-based proteomics analyses for diagnosis of Babesia canis canis infections in dogs. The study was conducted on two groups of dogs--healthy dogs and dogs infected with B. canis canis which demonstrated symptoms of babesiosis. The matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) MS technique revealed the presence of a protein fraction of 51-52 kDa in the blood serum of all the animals infected with the protozoa, which was not found in the serum of healthy dogs. The proteins are suspected to be disease markers, whereas the MALDI-TOF technique itself has high specificity and sensitivity and can be applied in analytical laboratories in the diagnosis of canine babesiosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25238794/