Are Image-Based Deep Learning Algorithms of Kidney Volume in Polycystic Kidney Disease Ready for Clinical Deployment? A Systematic Review and Meta-Analysis.

Abstract

<b>Objectives:</b> In patients with autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV) is the gold standard biomarker for assessing the risk of progression and the need for drug therapy. However, it is a time-consuming process. In this systematic review and meta-analysis, we evaluate the current state of deep learning (DL) algorithms for automatic kidney volume segmentation. <b>Methods:</b> All original research, including the search terms ADPKD, diagnostic imaging, DL, and TKV, was identified in PubMed, Embase, and Ovid MEDLINE databases from January 2000 to 13 October 2024. Articles with insufficient information to assess methodological quality were excluded. Quality was assessed using the "Quality Assessment of Diagnostic Accuracy Studies, Version 2" (QUADAS-2) and Checklist for Artificial Intelligence in Medical Imaging (CLAIM) tools. We focused on the Dice Similarity Coefficient (DSC), bias differences, and time efficiency as outcomes. <b>Results:</b> Nineteen studies were included, with an overall low risk of bias; however, the mean adherence to the CLAIM checklist was 64%. The pooled DSC under the random-effects model was 0.953 (95% CI: 0.938-0.969) with relatively low bias for TKV in 5622 ADPKD patients (mean age, 46.1 years; 45% male) and 9180 scans (79% MRI). The average segmentation time was decreased by 75% compared to the ground truth. Performance differences were evident among imaging modalities, MRI sequences, and 3D vs. 2D models, but not among imaging planes. The between-study heterogeneity was low (I2=0%), and no statistically significant evidence of small-study effects or publication bias was detected. <b>Conclusions:</b> DL models for TKV in ADPKD patients demonstrated high precision compared to manual segmentation in a large, pooled sample with heterogeneous study designs and methods. While clinical implementation is not yet feasible, the current work demonstrates the technical and diagnostic efficacy of image-based DL segmentation models.