Correlation between skin water loss and symptoms in dogs with atopic

Abstract

BACKGROUND: Cutaneous impairment plays a crucial role in atopic dermatitis (AD). Transepidermal water loss (TEWL) measurement is an indirect assessment of skin barrier function and correlates with disease severity in humans. Skin impairment also exists in canine AD; however, concerns exist regarding variability and reliability of TEWL measurements in dogs. HYPOTHESIS/OBJECTIVES: The purposes of this retrospective study were twofold: first, to investigate the correlation between severity of dermatitis [measured by Canine Atopic Dermatitis Extent and Severity Index (CADESI)] and TEWL; and second, to evaluate whether increased TEWL at a young age correlates with disease severity later in life. METHODS: Data from atopic beagles and dogs with natural AD were analysed. Transepidermal water loss was measured in atopic beagles (n=24) with an open chamber and in dogs with naturally occurring AD with a closed chamber device (two studies, with n=14 and n=18). Pearson product-moment correlation was used for analyses. Transepidermal water loss of the inguinal region, axilla, antebrachial flexure and pinna was analysed. Correlations were investigated for each study, separately first and then jointly. They included CADESI and TEWL of individual regions, total CADESI and total TEWL of all measured regions, and total CADESI and TEWL of key regions. RESULTS: In atopic beagles, TEWL measured at 1 year of age pre- and post-allergen challenge was correlated with CADESI at 1, 3 and 6 years of age. Overall, low correlation coefficients were found; therefore, a biologically relevant connection could not be demonstrated. The main significant positive correlation was found between TEWL in the pinna and total CADESI. CONCLUSIONS AND CLINICAL IMPORTANCE: It is concluded that TEWL does not correlate with disease severity.