Peer-reviewed veterinary case report
Arterionecrosis of the equine mesentery in naturally occurring endotoxaemia.
- Journal:
- Journal of comparative pathology
- Year:
- 2004
- Authors:
- Oikawa, M et al.
- Affiliation:
- Equine Research Institute · Japan
- Species:
- horse
Plain-English summary
This report talks about a Thoroughbred racehorse that developed serious blood vessel damage in its intestines due to endotoxaemia, which is a condition caused by toxins in the blood often linked to colic (abdominal pain). The damage involved a significant loss of muscle cells in the small blood vessels, along with signs of cell death and other changes in the blood vessel walls. The findings in this horse were similar to those seen in other cases of endotoxaemia in horses and even in some diseases affecting pigs and humans. The outcome of this case is not specified, but it highlights the serious nature of the condition.
Abstract
This report describes the mesenteric arteriolar lesions in a Thoroughbred racehorse with endotoxaemia due to colic. The vascular lesions consisted of a striking loss of medial smooth muscle cells, associated with granular cell debris derived from necrosed muscle cells, plasma insudation, erythrocyte infiltration and the deposition of a fibrinoid substance (fibrinoid degeneration) in the entire arterial wall, possibly produced by the infiltration of blood components through endothelial cell junctions into the arterial wall. The morphology of the mesenteric arteriolar necrosis closely resembled that seen in experimental equine endotoxaemia and in horses that died from colic; it also resembled that of Shiga toxin-induced arteriolar lesions in oedema disease of swine and of the arterionecrosis in human cerebral arteries that may lead to hypertensive intracerebral haemorrhage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14693128/