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Peer-reviewed veterinary case report

Asparaginase-associated pancreatitis in a dog.

Journal:
The Canadian veterinary journal = La revue veterinaire canadienne
Year:
2011
Authors:
Schleis, Stephanie E et al.
Affiliation:
Department of Clinical Sciences · United States
Species:
dog

Abstract

A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/22379203/