Peer-reviewed veterinary case report
Dog with vomiting and abdominal pain after L-asparaginase treatment
By Schleis, Stephanie E et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2011·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Asparaginase-associated pancreatitis in a dog.
- Species:
- dog
Plain-English summary
A dog with lymphosarcoma started vomiting, seemed lethargic, and showed signs of abdominal pain two days after receiving a treatment called L-asparaginase. The veterinarian diagnosed the dog with pancreatitis, which is inflammation of the pancreas, likely caused by the medication. This condition is known to occur as a side effect of L-asparaginase, although it isn't well-studied in pets. The dog’s symptoms were linked to the treatment, and the vet will likely monitor and manage the condition closely.
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Abstract
A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22379203/