Peer-reviewed veterinary case report
Changes in blood flow in dog sarcomas and carcinomas during radiation
By Ohlerth, Stefanie et al.·Published in Veterinary journal (London, England : 1997)·2010·Vetsuisse Faculty·View original on PubMed →
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Original publication title: Assessment of changes in vascularity and blood volume in canine sarcomas and squamous cell carcinomas during fractionated radiation therapy using quantified contrast-enhanced power Doppler ultrasonography: a preliminary study.
- Species:
- dog
Plain-English summary
A group of dogs with oral fibrosarcomas and squamous cell carcinomas underwent radiation therapy to treat their tumors. Researchers used ultrasound to measure changes in blood flow and tumor size during treatment. While the tumors shrank significantly by the end of the therapy, the blood flow and vascularity showed only minor changes. This study suggests that while radiation therapy effectively reduces tumor size, it does not significantly alter blood flow in these types of tumors.
People also search for: dog oral fibrosarcoma treatment · squamous cell carcinoma in dogs · radiation therapy for dog tumors
Abstract
Radiation therapy does not only target tumour cells but also affects tumour vascularity. In the present study, changes in tumour vascularity and blood volume were investigated in five grade 1 oral fibrosarcomas, eight other sarcomas (non-oral soft tissue and bone sarcomas) and 12 squamous cell carcinomas in dogs during fractionated radiation therapy (total dose, 45-56 Gy). Contrast-enhanced power Doppler ultrasound was performed before fraction 1, 3, 6, 8, 10, 12, 14 and 15 or 16 (sarcomas) or 17 (squamous cell carcinomas). Prior to treatment, median vascularity and blood volume were significantly higher in squamous cell carcinomas (P=0.0005 and 0.001), whereas measurements did not differ between oral fibrosarcomas and other sarcomas (P=0.88 and 0.999). During the course of radiation therapy, only small, non-significant changes in vascularity and blood volume were observed in all three tumour histology groups (P=0.08 and P=0.213), whereas median tumour volume significantly decreased until the end of treatment (P=0.04 for fibrosarcomas and other sarcomas, P=0.008 for squamous cell carcinomas). It appeared that there was a proportional decrease in tumour volume, vascularity and blood volume. Doppler measurements did not predict progression free interval or survival in any of the three tumour groups (P=0.06-0.86). However, the number of tumours investigated was small and therefore, the results can only be considered preliminary.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19692273/