Peer-reviewed veterinary case report
Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury.
- Journal:
- Stem cells translational medicine
- Year:
- 2025
- Authors:
- Lou, Zijian et al.
- Affiliation:
- Krembil Brain Institute · Canada
Abstract
Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39931999/