Peer-reviewed veterinary case report
Stem cell treatment tested for chronic kidney disease in cats
By Quimby, Jessica M et al.·Published in Journal of Feline Medicine and Surgery·2015·Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA, United States·View original on Crossref →
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Original publication title: Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats
- Species:
- cat
Plain-English summary
An 8-year-old cat with chronic kidney disease (CKD) was part of a study to see if treatment with stem cells from fat tissue could help improve kidney function. The cat received three doses of these stem cells over six weeks, while another group received a placebo. Although the treatment did not cause any side effects, it also did not show significant improvement in kidney function right away. More research is needed to see if this treatment might help cats with CKD in the long run.
People also search for: cat chronic kidney disease treatment · stem cell therapy for cats · feline kidney disease management
Abstract
Objectives Feline chronic kidney disease (CKD) is characterized by chronic tubulointerstitial nephritis, and inflammation contributes to the progression of renal fibrosis. Mesenchymal stem cells (MSCs) have demonstrated anti-inflammatory and antifibrotic effects in rodent CKD models. However, few randomized trials evaluating the effectiveness of MSC therapy for diseases in companion animals have been reported. The purpose of this study was to evaluate the effectiveness of allogeneic MSCs for the treatment of feline CKD using a randomized, placebo-controlled trial. Methods MSCs were isolated from the cryopreserved adipose tissues of specific pathogen-free research cats and culture expanded. CKD cats were enrolled in a randomized, placebo-controlled, blinded one-way crossover clinical study. Four CKD cats were randomized to receive 2 × 10 6 MSCs/kg intravenously at 2, 4 and 6 weeks. Four CKD cats were randomized to receive placebo, with two cats crossing over to the MSC treatment group and one cat failing to complete the trial. Complete blood counts, chemistry and urinalysis were performed at weeks 0, 2, 4, 6 and 8. Glomerular filtration rate (GFR) via nuclear scintigraphy and urine protein:creatinine ratio (UPC) were determined at weeks 0 and 8. Results Six cats received three doses of allogeneic MSC culture expanded from cryopreserved adipose without adverse effects. No significant change in serum creatinine, blood urea nitrogen, potassium, phosphorus, GFR by nuclear scintigraphy, UPC or packed cell volume was seen in cats treated with MSCs. Individual changes in GFR were 12%, 8%, 8%, 2%, –13% and –67% in treated cats compared with 16%, 36% and 0% in placebo-treated cats. Conclusions and relevance While administration of MSC culture expanded from cryopreserved adipose was not associated with adverse effects, significant improvement in renal function was not observed immediately after administration. Long-term follow-up is necessary to determine whether MSC administration affects disease progression in cats with CKD.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x15576980