Peer-reviewed veterinary case report
Plasma lactate and temperature changes in dogs with mitral valve
By Soares, Felipe B et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2018·Veterinary Hospital of the Faculty of Agronomy and Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Assessment of plasma lactate and core-peripheral temperature gradient in association with stages of naturally occurring myxomatous mitral valve disease in dogs.
- Species:
- dog
Plain-English summary
A 7-year-old dog with heart failure due to myxomatous mitral valve disease (MMVD) was studied to understand how certain blood tests relate to the severity of the disease. The researchers found that dogs in the more severe stage (stage C) had higher levels of plasma lactate, which can indicate poor blood flow to tissues, compared to those in an earlier stage (stage B2) and healthy dogs. However, there were no significant differences in body temperature between the groups. This suggests that dogs with advanced MMVD may experience hidden issues with blood flow, which could be important for treatment decisions.
People also search for: dog heart failure symptoms · myxomatous mitral valve disease in dogs · elevated lactate levels in dogs
Abstract
OBJECTIVE: To evaluate plasma lactate concentrations and core-peripheral temperature gradients as perfusion parameters in dogs with heart failure caused by myxomatous mitral valve disease (MMVD) and to determine whether the above perfusion parameters are correlated with disease stages. DESIGN: Prospective observational study. SETTING: University teaching hospital. ANIMALS: After excluding 129 dogs because of exclusion criteria, 7 dogs with heart failure classified as stage B2 and 10 dogs classified as stage C according to the American Heart Association (AHA)/American College of Cardiology (ACC) were included in the study. Six dogs without MMVD were evaluated as the control group. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the evaluated parameters, the plasma lactate concentrations were increased in stage C (median 3.70 mmol/L [33.3 mg/dL], interquartile range (IQR) 0.72 mmol/L [6.5 mg/dL]) compared with those in the control (median 2.80 mmol/L [25.2 mg/dL], IQR 0.8 mmol/L [7.2 mg/dL]; P = 0.024) and stage B2 groups (median 2.70 mmol/L [24.3 mg/dL], IQR 1.8 mmol/L [16.2 mg/dL]; P = 0.045). Significant differences were not observed in the core-peripheral temperature gradients among the control, stage B2, and stage C dogs. CONCLUSIONS: Dogs with structural heart disease as a result of MMVD may have occult tissue hypoperfusion in stage C that is demonstrated by hyperlactatemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30294857/