Peer-reviewed veterinary case report
Serotonin levels in dogs with mitral valve disease and lung
By Nattawan Tangmahakul et al.·Published in Frontiers in Veterinary Science·2021·Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand, CH·View original on DOAJ →
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Original publication title: Assessment of Platelet and Plasma Serotonin in Canine Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease
- Species:
- dog
Plain-English summary
A group of small-breed dogs with degenerative mitral valve disease (DMVD) was studied to see how their serotonin levels in platelets related to pulmonary hypertension (PH), a common complication of this heart condition. The research found that dogs with DMVD and a high likelihood of PH had lower levels of serotonin in their platelets compared to those with DMVD alone. However, the overall serotonin levels in their plasma did not show significant differences. This suggests that monitoring platelet serotonin levels could be important for understanding the severity of PH in dogs with DMVD.
People also search for: dog heart disease symptoms · pulmonary hypertension in dogs · serotonin levels in dogs with heart problems
Abstract
Background: Pulmonary hypertension (PH) is a common complication of degenerative mitral valve disease (DMVD), the most common cardiovascular disease in dogs. Serotonin has been suspected to play a role in the pathogenesis of PH, so this study aimed to investigate the differences in platelet and plasma serotonin between normal, DMVD and DMVD with PH (DMVD+PH) dogs.Materials and Methods: Sixty-two small-breed dogs were enrolled to the study and divided into the normal (n = 22), DMVD (n = 20), and DMVD+PH (n = 20) groups. The platelet and plasma serotonin concentrations were measured by the competitive ELISA.Results: The Kruskal–Wallis revealed the difference among the four groups of normal (179.73 [102.37–352.24] ng/109 platelets), DMVD (325.99 [96.84–407.66] ng/109 platelets), DMVD with intermediate probability of PH (291.11 [106.69–400.84] ng/109 platelets) and DMVD with high probability of PH (35.82 [2.69–126.35] ng/109 platelets) (p = 0.014). The Dunn's post-hoc test showed a decrease in the platelet serotonin concentration of the DMVD dogs with high probability of PH compared to the DMVD group (p = 0.008). The plasma serotonin concentration was not different between normal, DMVD, and DMVD+PH dogs.Conclusion: In conclusion, a decrease in platelet serotonin concentration, which is associated with a degree of PH probability was found in DMVD dogs with PH. Further studies investigating roles of platelet serotonin in PH secondary to DMVD should be performed.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2021.695492