Peer-reviewed veterinary case report
Serotonin levels in dogs with mitral valve disease and lung
By Tangmahakul, Nattawan et al.·Published in Frontiers in veterinary science·2021·Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Assessment of Platelet and Plasma Serotonin in Canine Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease.
- Species:
- dog
Plain-English summary
A group of small-breed dogs with degenerative mitral valve disease (DMVD) were studied to see how their serotonin levels in platelets related to pulmonary hypertension (PH), a common complication of DMVD. The researchers found that dogs with DMVD and a high likelihood of PH had lower serotonin levels in their platelets compared to those with just DMVD. However, the overall serotonin levels in the blood plasma did not show significant differences among the groups. This suggests that lower platelet serotonin might be linked to the severity of PH in dogs with DMVD, indicating a need for further research on this connection.
People also search for: dog pulmonary hypertension symptoms · small breed dog heart disease · serotonin levels in dogs with heart problems
Abstract
Pulmonary hypertension (PH) is a common complication of degenerative mitral valve disease (DMVD), the most common cardiovascular disease in dogs. Serotonin has been suspected to play a role in the pathogenesis of PH, so this study aimed to investigate the differences in platelet and plasma serotonin between normal, DMVD and DMVD with PH (DMVD+PH) dogs.Sixty-two small-breed dogs were enrolled to the study and divided into the normal (= 22), DMVD (= 20), and DMVD+PH (= 20) groups. The platelet and plasma serotonin concentrations were measured by the competitive ELISA.The Kruskal-Wallis revealed the difference among the four groups of normal (179.73 [102.37-352.24] ng/10platelets), DMVD (325.99 [96.84-407.66] ng/10platelets), DMVD with intermediate probability of PH (291.11 [106.69-400.84] ng/10platelets) and DMVD with high probability of PH (35.82 [2.69-126.35] ng/10platelets) (= 0.014). The Dunn'stest showed a decrease in the platelet serotonin concentration of the DMVD dogs with high probability of PH compared to the DMVD group (= 0.008). The plasma serotonin concentration was not different between normal, DMVD, and DMVD+PH dogs.In conclusion, a decrease in platelet serotonin concentration, which is associated with a degree of PH probability was found in DMVD dogs with PH. Further studies investigating roles of platelet serotonin in PH secondary to DMVD should be performed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34212025/