Peer-reviewed veterinary case report
Assessment of prion inactivation by fenton reaction using protein misfolding cyclic amplification and bioassay.
- Journal:
- Bioscience, biotechnology, and biochemistry
- Year:
- 2007
- Authors:
- Suyama, Kyozo et al.
- Affiliation:
- Sports Nutrition Department · Japan
Abstract
An abnormal isoform of the prion protein, associated with transmissible spongiform encephalopathies, retains infectivity even after undergoing routine sterilization processes. We found that a formulation of iron ions combined with hydrogen peroxide effectively reduced infectivity and the level of abnormal isoforms of the prion protein in scrapie-infected brain homogenates. Therefore, the Fenton reaction has potential for prion decontamination.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17690456/