Peer-reviewed veterinary case report
Assessment of Rhinovirus Infection in a Mouse Model of COPD.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2025
- Authors:
- Antunes, Krist H et al.
- Affiliation:
- Pontifical Catholic University of Rio Grande do Sul · Brazil
Abstract
A better understanding of the mechanisms governing virus-induced exacerbations of chronic obstructive pulmonary disease (COPD) is urgently needed to develop more effective therapeutic approaches. Animal models are invaluable tools for gaining mechanistic insight into innate immunity. Here, we describe the methods required to establish a short-term mouse model comprising elastase administration to induce features of COPD, combined with infection using the minor group rhinovirus serotype A1 (RV-A1). This model recapitulates the hallmark features of human virus-induced COPD exacerbation and facilitates the study of mechanisms that drive these episodes.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40016465/