Peer-reviewed veterinary case report
Assessment of rodents as animal models for Reston ebolavirus.
- Journal:
- The Journal of infectious diseases
- Year:
- 2011
- Authors:
- de Wit, Emmie et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
- Species:
- rodent
Abstract
The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-)(/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-)(/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21987777/