Peer-reviewed veterinary case report
Kidney test changes in hyperthyroid cats after radioiodine treatment
By Yu, Lucia et al.·Published in Journal of veterinary internal medicine·2020·Faculty of Veterinary and Agricultural Sciences, Australia·View original on PubMed →
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Original publication title: Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine.
- Species:
- cat
Plain-English summary
An 8-year-old hyperthyroid cat was monitored for kidney function before and after receiving a fixed dose of radioiodine treatment. The vet measured levels of certain substances in the cat's blood, including symmetric dimethylarginine (SDMA) and creatinine, which help assess kidney health. After treatment, the SDMA levels increased for most cats, but some showed improvement, while only a few had lower creatinine levels. This suggests that SDMA might not be a reliable indicator of kidney function in hyperthyroid cats after treatment, so vets should consider other factors when evaluating kidney health in these pets.
People also search for: cat hyperthyroidism treatment · cat kidney function test results · SDMA levels in cats · radioiodine for hyperthyroid cats
Abstract
BACKGROUND: Serum symmetric dimethylarginine (SDMA) is a sensitive renal biomarker for detecting early chronic kidney disease (CKD) in nonhyperthyroid cats, but knowledge regarding its performance in hyperthyroid cats remains limited. OBJECTIVES: To determine the relationship between serum SDMA, creatinine and total thyroxine (TT4) concentrations in hyperthyroid cats before (T0) and 3 months after (T1) receiving a PO fixed dose of radioiodine. ANIMALS: Eighty client-owned hyperthyroid cats. METHODS: Prospective cohort study. Serum TT4, and SDMA, creatinine concentrations, and urine specific gravity were measured at T0 and T1. Nonparametric tests were used to determine the relationship among SDMA, and creatinine and TT4 concentrations. Agreement between SDMA and creatinine regarding CKD staging at both time points was assessed using Goodman and Kruskal's gamma statistic. RESULTS: Mean serum SDMA concentration increased after treatment of hyperthyroidism. However, 21 of 75 cats experienced a decrease in SDMA between T0 and T1, whereas creatinine decreased in only 2 cats. A moderate correlation between SDMA and creatinine was seen at T1 (r = 0.53; P < .001) but not at T0 (r = 0.13; P = .25). Where assessable at T1, poor agreement was observed between SDMA and creatinine and CKD stage (Goodman and Kruskal's gamma 0.20; P = .29). CONCLUSIONS AND CLINICAL IMPORTANCE: Discordant outcomes between SDMA and creatinine after radioiodine treatment in cats with hyperthyroidism suggest extrarenal factors may interfere with the reliability of SDMA to adequately reflect renal function. As a result, SDMA should not be interpreted in isolation in hyperthyroid cats treated with radioiodine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32506701/