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Peer-reviewed veterinary case report

Symmetric dimethylarginine detects kidney function in hyperthyroid

By Buresova, Eva et al.·Published in Journal of veterinary internal medicine·2019·The Small Animal Department·View original on PubMed →

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Original publication title: Assessment of symmetric dimethylarginine as a biomarker of renal function in hyperthyroid cats treated with radioiodine.

Species:
cat
Feline hyperthyroidismChronic kidney disease in catsDrinking & peeingCats

Plain-English summary

A group of 47 hyperthyroid cats were tested for kidney function before and one month after receiving radioiodine treatment. While serum symmetric dimethylarginine (sSDMA) levels were elevated in some cats before treatment, they returned to normal in most after the hyperthyroidism was treated. However, the study found that sSDMA was not a reliable indicator of kidney function in these cats, as it did not correlate well with other kidney function tests. All cats remained stable and did not show signs of worsening kidney disease after treatment.

People also search for: hyperthyroid cat kidney function · cat radioiodine treatment · elevated sSDMA in cats · cat kidney disease symptoms · hyperthyroidism treatment in cats

Abstract

BACKGROUND: Measurement of serum creatinine (sCr) and urea nitrogen fail to detect decreased renal function in many hyperthyroid cats because of low muscle mass and glomerular hyperfiltration of affected cats. Serum symmetric dimethylarginine (sSDMA) is an earlier and more sensitive renal biomarker than sCr. OBJECTIVE: Evaluate sSDMA as a biomarker of renal function in hyperthyroid cats before (T0) and 1&#x2009;month after (T1) radioiodine (I) treatment. ANIMALS: Forty-seven client-owned hyperthyroid nonazotemic cats were evaluated at T0 and T1. METHODS: A prospective study in which sCr and sSDMA concentrations were determined in 47 hyperthyroid cats at T0 and at T1. Glomerular filtration rate (GFR) was estimated at T0 and T1 in 10 of these 47 cats using plasma exogenous creatinine clearance test. RESULTS: Serum SDMA was elevated (>14&#x2009;&#x3bc;g/dL) in 6 of 47 cats at T0 and normalized after treatment in 4 of those cats. All cats remained nonazotemic after treatment. In 10 cats in which GFR was measured, correlation between GFR and sSDMA was low and not significant (&#x3c4;&#x2009;=&#x2009;-0.35, P&#x2009;=&#x2009;.17 at T0 and &#x3c4;&#x2009;=&#x2009;-.22, P&#x2009;=&#x2009;.41 at T1), whereas correlation between GFR and sCr was moderate and significant (&#x3c4;&#x2009;=&#x2009;-0.52, P&#x2009;<&#x2009;.05 at T0 and &#x3c4;&#x2009;=&#x2009;-.53, P&#x2009;=&#x2009;<.05 at T1). CONCLUSIONS AND CLINICAL IMPORTANCE: Careful interpretation of mildly increased sSDMA with normal sCr in hyperthyroid cats is warranted as sSDMA values might normalize after resolution of hyperthyroidism in some cats. In this population of hyperthyroid cats, sSDMA was poorly correlated with GFR.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30632628/

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