Peer-reviewed veterinary case report
Interleukin-8 levels in dogs with tracheal collapse
By Toone, Erin et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Assessment of the circulating inflammatory mediator interleukin-8 in dogs with tracheal collapse.
- Species:
- dog
Plain-English summary
A group of dogs with tracheal collapse, a condition that causes breathing problems, was found to have higher levels of a protein called interleukin-8 (IL-8) in their blood compared to healthy dogs. This suggests that dogs with tracheal collapse may experience systemic inflammation, which can affect their overall health and quality of life. The study included Yorkshire terriers, who were more common in the affected group, and noted that older dogs with a higher body condition score had this increased IL-8. Understanding IL-8 levels could help veterinarians monitor the progression of tracheal collapse and how well treatments are working.
People also search for: dog breathing problems · tracheal collapse in Yorkshire terriers · interleukin-8 in dogs · dog cough treatment
Abstract
OBJECTIVE: Tracheal collapse (TC) is an obstructive respiratory disorder in dogs that can affect lifespan and quality of life. Systemic inflammation has been identified in other obstructive airway conditions in dogs and humans. We hypothesized a systemic pro-inflammatory state exists in dogs with TC. ANIMALS: Dogs with TC (TC,= 15) and healthy, non-affected controls (C,= 15), were prospectively enrolled. PROCEDURE: Signalment and body condition score (BCS) were recorded for all dogs. For TC dogs, cough duration, pharyngeal collapse, bronchial collapse, and previous stent placement were recorded. Plasma samples were banked at -80°C and batch-analyzed for interleukin-8 (IL-8). Differences between groups were evaluated. RESULTS: Yorkshire terriers were overrepresented in the TC group. The TC group was older than the C group and had a higher BCS. Interleukin-8 was significantly greater in the TC compared to the C group. Interleukin-8 was not correlated with age sex, BCS, breed, cough duration, pharyngeal collapse, bronchial collapse, or stent placement. CONCLUSION AND CLINICAL RELEVANCE: Increased plasma IL-8 concentration supports the presence of systemic inflammation in canine TC. Dogs with TC were older than controls, with a higher BCS, but this did not account for the increased IL-8. Further investigation of IL-8 as a potential biomarker for monitoring TC progression and therapeutic response is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39355696/