Peer-reviewed veterinary case report
Stem cell hip injections improve limb function in dogs
By Vilar, Jose M et al.·Published in BMC veterinary research·2014·Department of Animal Pathology, Spain·View original on PubMed →
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Original publication title: Assessment of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells in osteoarthritic dogs using a double blinded force platform analysis.
- Species:
- dog
Plain-English summary
A group of ten dogs with severe hip osteoarthritis (OA) received injections of their own fat-derived stem cells to help improve their limping and overall limb function. Within the first month after treatment, these dogs showed a noticeable improvement in their ability to bear weight on the affected leg, with a 9% increase in peak vertical force. However, the benefits began to decrease after about three months, returning to initial levels. This treatment provided a temporary but significant boost in mobility for dogs suffering from hip OA.
People also search for: dog limping treatment · stem cell therapy for dog arthritis · hip osteoarthritis in dogs · how to help my dog with joint pain
Abstract
BACKGROUND: Regenerative medicine using Mesenchymal Stem Cells (MSC) alone or combined with Plasma Rich in Growth Factors (PRGF) is a rapidly growing area of clinical research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify and quantify the efficacy of different therapeutic strategies for the treatment of OA in dogs including MSC associated to PRGF, but never with AD-MSC alone. The aim of this study was to use a force platform to measure the efficacy of intraarticular ADMSC administration for limb function improvement in dogs with severe OA. RESULTS: Ten lame dogs with severe hip OA and a control group of 5 sound dogs were used for this study. Results were statistically analyzed to detect a significant increase in peak vertical force (PVF) and vertical impulse (VI) in treated dogs. Mean values of PVF and VI were significantly improved within the first three months post-treatment in the OA group, increasing 9% and 2.5% body weight, respectively, at day 30. After this, the effect seems to decrease reaching initial values. CONCLUSION: Intraarticular ADMSC therapy objectively improved limb function in dogs with hip OA. The duration of maximal effect was less than 3 months.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24984756/