Peer-reviewed veterinary case report
How fast afoxolaner kills adult fleas on dogs
By Kunkle, Bruce N et al.·Published in Veterinary parasitology·2014·Merial Limited, United States·View original on PubMed →
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Original publication title: Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs.
- Species:
- dog
Plain-English summary
A group of 40 beagles with flea infestations were treated with a chewable medication called afoxolaner to see how quickly it could kill fleas. The dogs were infested with about 100 fleas and then given the treatment. Within just 2 hours, the afoxolaner started to reduce the number of fleas, and by 8 hours, it was over 99% effective at killing them. This means that afoxolaner works very quickly to help get rid of fleas on dogs, making it a great option for flea control.
People also search for: dog flea treatment afoxolaner · how fast does afoxolaner work · beagle flea infestation treatment
Abstract
The speed of kill of afoxolaner against experimental infestations by Ctenocephalides felis was evaluated after oral administration of afoxolaner in a soft chew (NEXGARD(®)) at a dose to achieve 2.5mg/kg bodyweight. Forty beagles were allocated to two treatment groups. Dogs in Treatment Group 1 were untreated controls. Dogs in Treatment Group 2 were treated on Day-0 with afoxolaner, according to their pre-treatment bodyweight. All dogs were infested with approximately 100 C. felis on Day-1. Live fleas were counted upon removal at 5 time points after treatment (i.e., 2, 4, 8, 12 and 24h after treatment). For each time point, counts were performed on 4 dogs from each of the treated and the untreated groups. Early curative flea killing efficacy was evaluated with respect to the untreated control group. The afoxolaner treated group had significantly fewer fleas than the untreated control group at 8, 12, and 24h (p<0.001). The percent efficacies of orally administered afoxolaner were 15.0%, 87.8%, 99.5%, 100.0%, and 100.0% at 2, 4, 8, 12, and 24h, respectively. In this study, afoxolaner began killing fleas by 2h after treatment with increasing efficacy at subsequent time points and had >99.5% efficacy at 8, 12, and 24h after treatment demonstrating an early onset of action.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24685322/