Peer-reviewed veterinary case report
Outcomes of fixed-dose oral radioiodine treatment in hyperthyroid cats
By Yu, Lucia et al.·Published in Journal of feline medicine and surgery·2020·Faculty of Veterinary and Agricultural Sciences, Australia·View original on PubMed →
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Original publication title: Assessment of treatment outcomes in hyperthyroid cats treated with an orally administered fixed dose of radioiodine.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were treated with a fixed dose of radioiodine to see how well it worked in lowering their thyroid hormone levels. After treatment, about 82% of the cats had normal thyroid hormone levels, while a small number still had high or low levels. The study found that the severity of hyperthyroidism at the start did not predict how well the treatment would work. More research is needed to improve the dosing of oral radioiodine for better results in these cats.
People also search for: cat hyperthyroidism treatment · radioiodine for cats · cat thyroid hormone levels
Abstract
OBJECTIVES: The aims of this study were to describe the treatment outcomes following oral administration of a fixed dose (138 MBq; 3.7 mCi) of radioiodine in hyperthyroid cats and to examine the correlation between total thyroxine (TT4) concentrations before and after treatment. METHODS: This was a retrospective cohort study that documented the TT4 concentration and clinicopathological parameters at the time of diagnosis and after treatment. Logistic regression was used to assess the relationship between TT4 concentrations before and after treatment. The difference in pre- and post-treatment variables between cats that had TT4 concentrations below or within the reference interval (RI) was compared by the Mann-Whitney U-test. RESULTS: Of 161 cats, 133 (82.6%) cats had TT4 concentrations within the RI, four (2.5%) cats had TT4 concentrations above the RI and 24 (14.9%) cats had TT4 concentrations below the RI after treatment. The severity of hyperthyroidism at diagnosis, as measured by the percentage of TT4 elevation above the upper limit of the RI, had no impact on the odds of cats having low TT4 concentrations after treatment (odds ratio 1.00; 95% confidence interval 0.96-1.05; 0.828). CONCLUSIONS AND RELEVANCE: When using an orally administered fixed dose of radioiodine for the treatment of feline hyperthyroidism, TT4 concentrations at diagnosis cannot be used to predict TT4 concentrations after treatment. The proportion of cats with TT4 concentrations below the lower limit of the RI after treatment was 14.9%. Further work is required to optimise oral radioiodine dosing to achieve maximal euthyroid outcomes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31680613/