Peer-reviewed veterinary case report
Gene changes linked to atopic dermatitis in Shiba Inu and Dachshund
By Tanaka, Kazuaki et al.·Published in The Journal of veterinary medical science·2020·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of miniature dachshunds with atopic dermatitis (a skin allergy condition) was studied to see if certain genetic variations in their interleukin-4 receptor (IL4R) gene were linked to the disease. Researchers found that one specific genetic variant (the A allele of rs24378020) might help protect against atopic dermatitis by affecting how the immune system responds. In contrast, shiba inus did not show this protective variant. This suggests that genetics can play a role in whether a dog develops skin allergies, particularly in miniature dachshunds.
People also search for: miniature dachshund skin allergies · dog atopic dermatitis genetics · shiba inu skin problems
Abstract
Interleukin-4 (IL4) and interleukin-13 (IL13) are involved in the initial response of T helper 2 lymphocytes through the activation of the IL4 receptor alpha (IL4RA), which is a common receptor chain for these cytokines. In humans, several single-nucleotide polymorphisms (SNPs) identified in the IL4R and in interleukin coding genes were associated with atopic disorders. However, the association between canine IL4R polymorphisms and atopic disorders has not been investigated yet. This study aimed to determine the associations between four non-synonymous SNPs and canine atopic dermatitis (CAD) in shiba inu and miniature dachshund populations. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis were used to genotype four polymorphisms of canine IL4R and IL13 in 34 shiba inu and 19 miniature dachshund patients with CAD, as well as 29 shiba inu and 39 miniature dachshund patients without the condition. Results from miniature dachshunds revealed a potential association between the presence of minor A allele rs24378020 and CAD (odds ratio, 0.10; 95% confidence interval, 0.01-0.85; P=0.0062). This CAD resistance allele led to an amino acid substitution (Arg688Cys) that could impair IL4 and IL13 signaling. In shiba inu patients, rs24378020 was fixed by homozygosity of the major G allele. No association was found between the remaining three evaluated SNPs and CAD. Nevertheless, the study suggests that the IL4R Cys688 variant reduces the risk of CAD in miniature dachshunds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32669513/