Peer-reviewed veterinary case report
Association between Hyperglycemia and Canine Serum Pancreatic Lipase Immunoreactivity Concentration in Diabetic Dogs.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2023
- Authors:
- Kim, Joonseok et al.
- Affiliation:
- College of Veterinary Medicine · South Korea
- Species:
- dog
Plain-English summary
This study looked at how high blood sugar levels might be linked to pancreatic inflammation in diabetic dogs. Researchers examined 26 diabetic dogs and found that about 19% had signs of pancreatitis, which is inflammation of the pancreas. Dogs with poorly controlled diabetes had much higher levels of a specific enzyme (cPLI) that indicates pancreatitis compared to those with well-managed diabetes. The study suggests that long-term high blood sugar could lead to inflammation in the pancreas, but it’s still unclear what this means for the dogs' health. Overall, the findings indicate a potential connection between high blood sugar and pancreatic issues in diabetic dogs.
Abstract
It has been reported that hypertriglyceridemia can partially mediate between diabetes mellitus (DM) and pancreatitis in dogs, implying that another mediator, such as chronic hyperglycemia, might exist. Therefore, this study aimed to evaluate the relationship between hyperglycemia and serum canine pancreatic lipase immunoreactivity (cPLI) concentration in diabetic dogs. This retrospective cohort study included 26 client-owned diabetic dogs, divided according to their serum fructosamine levels (<500 μmol/L = well-controlled DM group; ≥500 μmol/L = untreated or poorly controlled DM group). Five of the 26 DM dogs (19.2%) had serum cPLI concentrations consistent with pancreatitis, among which two showed ultrasonographic evidence of pancreatitis without clinical signs. The serum cPLI concentrations (median [interquartile range]) were significantly higher in the untreated or poorly controlled group (520 μg/L [179.76-1000 μg/L]) than in the well-controlled group (77 μg/L [32.22-244.6 μg/L], P = 0.0147). The serum fructosamine concentration was positively correlated with the serum cPLI concentration (r = 0.4816; P = 0.0127). Multivariate analysis revealed serum triglyceride and fructosamine concentrations were associated with the serum cPLI concentration. In conclusion, this study suggests that chronic hyperglycemia may induce pancreatic inflammation in diabetic dogs; however, the clinical significance of increased cPLI concentration is unknown.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37708476/