Peer-reviewed veterinary case report
High blood sugar linked to pancreas enzyme levels in diabetic dogs
By Kim, Joonseok et al.·Published in Journal of the American Animal Hospital Association·2023·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Association between Hyperglycemia and Canine Serum Pancreatic Lipase Immunoreactivity Concentration in Diabetic Dogs.
- Species:
- dog
Plain-English summary
A group of 26 diabetic dogs was studied to see if high blood sugar (hyperglycemia) was linked to increased levels of a specific enzyme (cPLI) that indicates pancreatitis. Among these dogs, 5 had elevated cPLI levels, suggesting potential pancreatitis, although only two showed signs of the condition on ultrasound. The dogs with poorly controlled diabetes had significantly higher cPLI levels compared to those with well-managed diabetes. This suggests that long-term high blood sugar may lead to inflammation of the pancreas in diabetic dogs, but more research is needed to understand the full impact of these findings.
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Abstract
It has been reported that hypertriglyceridemia can partially mediate between diabetes mellitus (DM) and pancreatitis in dogs, implying that another mediator, such as chronic hyperglycemia, might exist. Therefore, this study aimed to evaluate the relationship between hyperglycemia and serum canine pancreatic lipase immunoreactivity (cPLI) concentration in diabetic dogs. This retrospective cohort study included 26 client-owned diabetic dogs, divided according to their serum fructosamine levels (<500 μmol/L = well-controlled DM group; ≥500 μmol/L = untreated or poorly controlled DM group). Five of the 26 DM dogs (19.2%) had serum cPLI concentrations consistent with pancreatitis, among which two showed ultrasonographic evidence of pancreatitis without clinical signs. The serum cPLI concentrations (median [interquartile range]) were significantly higher in the untreated or poorly controlled group (520 μg/L [179.76-1000 μg/L]) than in the well-controlled group (77 μg/L [32.22-244.6 μg/L], P = 0.0147). The serum fructosamine concentration was positively correlated with the serum cPLI concentration (r = 0.4816; P = 0.0127). Multivariate analysis revealed serum triglyceride and fructosamine concentrations were associated with the serum cPLI concentration. In conclusion, this study suggests that chronic hyperglycemia may induce pancreatic inflammation in diabetic dogs; however, the clinical significance of increased cPLI concentration is unknown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37708476/