Peer-reviewed veterinary case report
Hyperlipidemia linked to calcium oxalate bladder stones in dogs
By Paulin, Mathieu V et al.·Published in Journal of veterinary internal medicine·2022·Department of Small Animal Clinical Sciences, Canada·View original on PubMed →
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Original publication title: Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with calcium oxalate (CaOx) bladder stones was studied to see if obesity and high fat levels in the blood (hyperlipidemia) were linked to these stones. The research found that dogs with higher triglyceride levels were more likely to have these stones, with the odds increasing significantly for each unit of triglycerides measured. This suggests that checking fat levels in the blood could help veterinarians better manage dogs with CaOx stones.
People also search for: dog bladder stones treatment · high triglycerides in dogs · calcium oxalate stones in dogs
Abstract
BACKGROUND: Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans. OBJECTIVES: To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client-owned dogs. ANIMALS: Dogs with (n = 55, U [uroliths]-dogs) and without (n = 39, UF [uroliths-free]-dogs) CaOx lower urinary tract uroliths. METHODS: Case-control study. U-dogs were retrospectively enrolled and compared to UF-dogs. Body condition score (BCS; 1-9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12-hour food withholding) were recorded in both groups. RESULTS: On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38-11.12) for each mmol/L of TG (P = .027), of 39 (95% CI 9.27-293.22) for each mmol/L of glycemia (P < .0001), and of 2.43 (95% CI 1.45-4.45) per unit of BCS (P = .002). In multivariable models, the effect of TG was retained when all breeds were included for analysis and odds of having uroliths increased by a factor of 4.34 per mmol/L of TG (95% CI 1.45-19.99; P = .02). CONCLUSIONS AND CLINICAL IMPORTANCE: Serum lipid screening in dogs diagnosed with CaOx uroliths might be recommended to improve their medical staging and management.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34854133/