Peer-reviewed veterinary case report
Nitric oxide enzyme levels in dogs with intestinal lymphangiectasia
By Nagahara, Takuro et al.·Published in The Journal of veterinary medical science·2022·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
- Species:
- dog
Plain-English summary
A group of dogs with intestinal issues, specifically lymphoplasmacytic enteritis (LPE), were studied to see if a certain enzyme related to nitric oxide (NO) was involved in a common complication called intestinal lymphangiectasia (IL). The researchers found that while the enzyme levels were higher in dogs with IL compared to healthy dogs, there was no significant difference between those with and without IL. This suggests that NO might not be the main cause of IL in these dogs, and other factors could be at play.
People also search for: dog intestinal lymphangiectasia symptoms · lymphoplasmacytic enteritis treatment in dogs · causes of dog intestinal problems
Abstract
Intestinal lymphangiectasia (IL) is a common complication in dogs. Since nitric oxide (NO) is known to relax the lymphatic vessel, we evaluated inducible NO synthase (iNOS) expression using immunohistochemistry in 13 dogs with lymphoplasmacytic enteritis (LPE) with or without IL. The duodenal iNOS expressing cells were significantly increased in dogs with IL-negative or IL-positive LPE dogs (P=0.025, P=0.007) compared with control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues. Based on these results, there is no clear evidence for the NO overproduction in the pathogenesis of IL in dogs with LPE. Factors other than NO could, thus, contribute to IL in dogs with LPE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34853261/