Peer-reviewed veterinary case report
Pancreatitis linked to chronic kidney disease in cats
By Dulude, Michael D et al.·Published in Journal of the American Veterinary Medical Association·2024·View original on PubMed →
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Original publication title: Association between pancreatitis and chronic kidney disease in cats: a retrospective review of 154 cats presented to a specialty hospital between October 1, 2017, and October 1, 2022.
- Species:
- cat
Plain-English summary
A study found that cats with pancreatitis often also have chronic kidney disease (CKD). In this review of 154 cats, those with pancreatitis had higher stages of CKD and higher creatinine levels compared to cats without pancreatitis. Older cats, especially those aged 10 to 20 years, were more likely to have both conditions. The research suggests that feeding cats a dry-food diet may be linked to pancreatitis. Addressing both pancreatitis and CKD together early on could help improve the health and reduce the costs of treatment for affected cats.
People also search for: cat pancreatitis symptoms · chronic kidney disease in cats · dry food diet for cats with pancreatitis · treating cat kidney disease · cat pancreatitis and kidney problems
Abstract
OBJECTIVE: To investigate an association between pancreatitis and chronic kidney disease (CKD) in cats. ANIMALS: 154 client-owned cats: 77 cats with pancreatitis and 77 control cats with no evidence of pancreatitis. METHODS: Retrospective record review from October 1, 2017, to October 1, 2022, including cats with gastrointestinal clinical signs, pancreatic lipase immunoreactivity (PLI) ≥ 8.8 μg/L or PLI 4.5 to 8.7 μg/L with sonographic evidence of pancreatitis. Control cats had a PLI ≤ 4.4 μg/L with no sonographic evidence of pancreatitis. RESULTS: Cats with pancreatitis had significantly higher International Renal Interest Society CKD stages than controls (P < .001; OR, 13 [95% CI, 6.3 to 31]), and mean creatinine was on average 0.79 mg/dL (95% CI, 0.56 to 1.0) higher than controls (P < .001; age covariate ANCOVA, P = .003). Odds of CKD in cats with pancreatitis compared to controls increased significantly with age (P = .002). Cats aged 10 to < 15 years and 15 to 20 years with pancreatitis had significantly higher prevalence of CKD stage 2 to 4 compared to controls (P < .001; OR, 10.9 [95% CI, 3.4 to 44]; and P = .001; OR, 66 [95% CI, 4.6 to > 1,000], respectively). Cats with pancreatitis had significantly more sonographic renal infarcts (P = .004; OR, 6.9 [95% CI, 1.8 to 46]) and concurrent diabetes mellitus (P = .002; OR, 6 [95% CI, 1.9 to 27]). Cats with pancreatitis were fed more exclusively dry-food diets compared to controls (P = .014). CLINICAL RELEVANCE: Pancreatitis is associated with CKD in cats. Investigating and treating these diseases concurrently early in the disease process may reduce morbidity and mortality due to progressive disease and expensive hospitalizations. Renal infarcts may be associated with pancreatitis in cats without overt cardiac disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38364374/