Peer-reviewed veterinary case report
Dog breeds linked to different grades of mast cell tumors
By Mochizuki, H et al.·Published in Veterinary and comparative oncology·2017·Department of Molecular Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Association of breed and histopathological grade in canine mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at mast cell tumors (MCTs) in dogs and found that certain breeds are more likely to develop these tumors, especially as they age. Male dogs and those that haven't been neutered are at a higher risk for more aggressive, high-grade tumors. Interestingly, Pugs tend to develop less aggressive, low to intermediate-grade tumors rather than high-grade ones. This suggests that genetics may play a role in how severe these tumors can be in different breeds.
People also search for: dog mast cell tumor breed risk · Pug tumor types · high-grade mast cell tumor treatment
Abstract
The aim of this study was to evaluate the relationship between breed and the histopathological grade of canine mast cell tumours (MCTs). A retrospective survey of pathology data of 9375 histopathologically confirmed diagnoses of cutaneous MCTs in the US was evaluated in the context of breed prevalence in over two million registered purebred dogs. Association of histopathological grade with breed, age, sex and spay/neuter status was assessed. The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high-grade tumours. A significant difference in the proportion of high-grade tumours between breeds was detected. The Pug was at significantly increased risk of developing low/intermediate-grade tumours, but not high-grade tumours, resulting in preponderance of less aggressive MCTs in this breed. The results of this study suggest a genetic association for the development of high-grade MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27198171/