Peer-reviewed veterinary case report
Common immune gene linked to hypothyroidism in dogs
By Kennedy, L J et al.·Published in Tissue antigens·2006·University of Manchester, United Kingdom·View original on PubMed →
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Original publication title: Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.
- Species:
- dog
Plain-English summary
A group of dogs with hypothyroidism, a condition that can cause symptoms like weight gain, lethargy, and skin problems, was studied to see if there was a genetic link. Researchers found a significant association between this condition and a specific genetic marker (DLA-DQA1*00101) in various breeds, including Doberman Pinschers. This suggests that certain dogs may be more prone to developing hypothyroidism due to their genetics. Understanding this link can help veterinarians identify at-risk dogs and manage their health more effectively.
People also search for: dog hypothyroidism symptoms · Doberman Pinscher thyroid problems · genetic testing for dog health
Abstract
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16774545/