Peer-reviewed veterinary case report
Gastric lymphoid hyperplasia linked to Helicobacter in dogs
By Biénès, Tom et al.·Published in Journal of veterinary internal medicine·2022·Centre Hospitalier Vé, France·View original on PubMed →
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Original publication title: Association of gastric lymphofollicular hyperplasia with Helicobacter-like organisms in dogs.
- Species:
- dog
Plain-English summary
A group of 288 dogs, including many young French Bulldogs, were examined for vomiting and other stomach issues. The study found that dogs with gastric lymphofollicular hyperplasia (a condition involving inflammation in the stomach) often had Helicobacter-like organisms present, especially in younger dogs. Vomiting was a common symptom in these cases. While the exact clinical significance of these findings is still being studied, it appears that treating the underlying infection may help alleviate symptoms.
People also search for: dog vomiting causes · French Bulldog stomach problems · Helicobacter treatment in dogs
Abstract
BACKGROUND: The relationships among gastric lymphoid follicular hyperplasia (GLFH), Helicobacter-like organisms (HLOs), and clinical signs have not been established in dogs. OBJECTIVES: To evaluate the epidemiologic, clinical, endoscopic, and histopathologic findings associated with GLFH in dogs, and determine the association of GLFH with HLOs and the French Bulldog (FB) breed. ANIMALS: Two hundred eighty-eight dogs that underwent gastroscopy between 2013 and 2016. METHODS: Retrospective, cross-sectional study. Gastric biopsy samples were reviewed and scored for inflammation and HLOs. Dogs were divided into 3 groups: group 1 (63 FBs), group 2 (45 non-FB brachycephalic dogs), and group 3 (180 nonbrachycephalic dogs). Variables were evaluated for their association with GLFH. RESULTS: Univariate analysis determined that intact males, young age, vomiting, gastroscopic findings (discoloration, hemorrhage, and ulcers), and histopathologic findings (gastric lamina propria lymphocytic infiltration and HLO score) were associated with GLFH (P ≤ .03). In the multivariate analysis, GLFH was associated with the HLO score (odds ratio [OR] > 5 for HLO scores 1-2 and >15 for HLO score of 3; P < .001), with vomiting (OR > 4; P = .01) but not with FB breed (P = .76) and age (P = .1). The HLO score was associated with younger age (P < .001). CONCLUSION AND CLINICAL IMPORTANCE: The HLO score was associated with a high GLFH score. Vomiting was associated with GLFH. Helicobacter-like organisms are highly prevalent in young dogs and GLFH is indirectly associated with this factor. Clinical relevance of the identification of GLFH and HLO remains to be determined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35194849/