Peer-reviewed veterinary case report
Hypothyroidism after hyperthyroid treatment linked to kidney issues
By Williams, T L et al.·Published in Journal of veterinary internal medicine·2010·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Association of iatrogenic hypothyroidism with azotemia and reduced survival time in cats treated for hyperthyroidism.
- Species:
- cat
Plain-English summary
A group of 80 cats with hyperthyroidism were studied to see if treatment could lead to low thyroid hormone levels (iatrogenic hypothyroidism) and kidney problems (azotemia). It was found that cats who developed low thyroid levels after treatment were more likely to have kidney issues compared to those who didn't. Additionally, cats with both low thyroid levels and kidney problems had shorter lifespans. This suggests that monitoring thyroid levels after hyperthyroidism treatment is important for the health and longevity of affected cats.
People also search for: cat hyperthyroidism treatment side effects · cat kidney problems after thyroid treatment · iatrogenic hypothyroidism in cats
Abstract
BACKGROUND: Iatrogenic hypothyroidism can occur after treatment of hyperthyroidism, and is correlated with a reduced glomerular filtration rate in humans and dogs. HYPOTHESIS: Cats with iatrogenic hypothyroidism after treatment for hyperthyroidism will have a greater incidence of azotemia than euthyroid cats. ANIMALS: Eighty client owned cats with hyperthyroidism. METHODS: Two retrospective studies. (1) Longitudinal study of 12 hyperthyroid cats treated with radioiodine (documented as euthyroid after treatment), to assess changes in plasma thyroid stimulating hormone (TSH) concentration over a 6-month follow-up period, (2) Cross-sectional study of 75 hyperthyroid cats (documented as euthyroid) 6 months after commencement of treatment for hyperthyroidism to identify the relationship between thyroid status and the development of azotemia. Kaplan-Meier survival analysis was performed to identify relationships between thyroid and renal status and survival. RESULTS: Plasma TSH concentrations were not suppressed in 7 of 8 cats with hypothyroidism 3 months after radioiodine treatment. The proportion of cats with azotemia was significantly (P= .028) greater in the hypothyroid (16 of 28) than the euthyroid group (14 of 47). Twenty-eight of 41 cats (68%) with plasma TT4 concentration below the laboratory reference range had an increased plasma TSH concentration. Hypothyroid cats that developed azotemia within the follow-up period had significantly (P= .018) shorter survival times (median survival time 456 days, range 231-1589 days) than those that remained nonazotemic (median survival time 905 days, range 316-1869 days). CONCLUSIONS AND CLINICAL IMPORTANCE: Iatrogenic hypothyroidism appears to contribute to the development of azotemia after treatment of hyperthyroidism, and reduced survival time in azotemic cats.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20695989/