Peer-reviewed veterinary case report
Association of IL-33 in modeling type-2 airway inflammation and pulmonary emphysema in mice.
- Journal:
- Immunity, inflammation and disease
- Year:
- 2024
- Authors:
- Miyaoka, Chika et al.
- Affiliation:
- Department of Respiratory Medicine · Japan
- Species:
- rodent
Abstract
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL-13), IL-4, and IL-5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL-33 level in the lung was higher than in other models. IL-33 and interferon-γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38652015/