Peer-reviewed veterinary case report
Ki67 test predicts outcome for dogs with medium-grade skin mast cell
By Maglennon, G A et al.·Published in Veterinary and comparative oncology·2008·Animal Health Trust, United Kingdom·View original on PubMed →
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Original publication title: Association of Ki67 index with prognosis for intermediate-grade canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at 163 dogs with intermediate-grade mast cell tumors (MCT), which are a type of skin tumor. The researchers found that a specific marker called Ki67 could help predict how well a dog might do after treatment. Dogs with a Ki67 index of 1.8% or lower had a very good chance of surviving for at least three years, while those with a higher index had a much lower survival rate. This means that if your dog has been diagnosed with an intermediate-grade MCT, knowing the Ki67 index can give you important information about their prognosis after surgery.
People also search for: dog mast cell tumor prognosis · Ki67 index in dogs · intermediate-grade mast cell tumor treatment
Abstract
Intermediate-grade mast cell tumours (MCT) represent a heterogeneous population of tumours. The prognosis for the majority of dogs is excellent following surgical excision, but a minority die because of their disease. A previous study identified Ki67 expression as a predictor of prognosis in all three grades of MCT. The purpose of this study was to validate those results in a new group of dogs, with intermediate-grade MCT only. Ki67 immunohistochemistry was performed on intermediate-grade MCT from 163 dogs with known outcome. Digital microscopy images were taken from each tumour, and an index calculated of Ki67-positive cells. Ki67 index as a binary variable with a cut-off value of 1.8% was confirmed to be associated with prognosis (hazard ratio = 19.1, P < 0.0001) for this cohort of dogs. The 1-year, 2-year and 3-year survival probabilities (with standard errors) of 127 dogs with a Ki67 index <or=1.8% were [0.95 (0.024), similar for all] and for 36 dogs with a Ki67 index >1.8% were 0.54 (0.100), 0.45 (0.101) and 0.33 (0.104), respectively.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19178685/