Peer-reviewed veterinary case report
Inflammation markers linked to mesh exposure after pelvic organ
By Yan Y et al.·2026·Department of Obstetrics and Gynecology, China·View original on Europe PMC →
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Original publication title: Association of Preoperative Inflammatory and Immune Markers with Mesh Exposure After Transvaginal Mesh Surgery for Pelvic Organ Prolapse.
Plain-English summary
This study looked at how certain blood markers might relate to the risk of mesh exposure after surgery for pelvic organ prolapse in women. It involved 206 patients who had surgery using a specific type of mesh. The researchers found that about 11% of these patients experienced mesh exposure. They discovered that lower counts of certain white blood cells (monocytes and lymphocytes) were linked to a higher risk of this issue, while a higher ratio of platelets to lymphocytes also increased the risk. In summary, having low levels of these blood markers and a high platelet-to-lymphocyte ratio was associated with a greater chance of mesh exposure after the surgery.
Abstract
<h4>Introduction and hypothesis</h4>This study was conducted to investigate the associations between baseline absolute monocyte count (AMC), absolute lymphocyte count (ALC), the platelet-to-lymphocyte ratio (PLR), and the risk of mesh exposure following transvaginal mesh (TVM) surgery for pelvic organ prolapse (POP).<h4>Methods</h4>This prospective cohort study included 206 symptomatic POP patients who underwent TVM treatment with titanium-coated polypropylene mesh (Tiloop) from June 2015 to December 2021 at Peking Union Medical College Hospital. Patients were classified into mesh exposure (n = 23) and non-exposure (n = 183) groups. Baseline hematological indicators, including AMC, ALC, PLR, the neutrophil-to-lymphocyte ratio, the lymphocyte-to-monocyte ratio, and the prognostic nutritional index, were recorded. Restricted cubic spline (RCS) analysis and Cox proportional hazards models were used to assess the associations between these indicators and mesh-exposure risk.<h4>Results</h4>Mesh exposure occurred in 11.2% of the patients. Significant differences in AMC, ALC, and PLR were detected between the exposure and non-exposure groups. RCS analysis revealed inverse linear associations between AMC and ALC and mesh exposure risk and a positive linear association for the PLR. Lower AMC (adjusted hazard ratio [aHR] = 0.424; 95% CI 0.228-0.786) and ALC (aHR = 0.422; 95% CI 0.255-0.698) were associated with increased mesh exposure risk, whereas higher PLR (aHR = 2.170; 95% CI 1.486-3.169) was associated with increased risk.<h4>Conclusion</h4>Low AMC and ALC and elevated PLR were independently associated with an increased risk of mesh exposure after TVM surgery.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41240110