Peer-reviewed veterinary case report
Association of Streptococcus equi with equine monocytes.
- Journal:
- Veterinary immunology and immunopathology
- Year:
- 2011
- Authors:
- Mérant, Catherine et al.
- Affiliation:
- University of Kentucky · United States
- Species:
- horse
Abstract
Streptococcus equi (Se), the cause of equine strangles, is highly resistant to phagocytosis by neutrophils and is usually classified as an extracellular pathogen. Large numbers of the organism in tonsillar tissues during the acute phase of the disease are completely eliminated during convalescence by mechanisms not yet understood. In this study we demonstrate in an opsono-bactericidal assay and by cytometry and confocal microscopy that Se is interiorized and killed by equine blood monocytes. This finding supports the hypotheses that adaptive immune clearance is mediated by tonsillar macrophages and that macrophages monocytes could serve as a vehicle for transport from the tonsil to local lymph nodes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21752476/