Peer-reviewed veterinary case report
Insulin and inflammation markers in Miniature Schnauzers with high
By Xenoulis, Panagiotis G et al.·Published in Journal of veterinary internal medicine·2022·Clinic of Medicine·View original on PubMed →
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Original publication title: Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet.
- Species:
- dog
Plain-English summary
A group of Miniature Schnauzers with high triglyceride levels (idiopathic hyperlipidemia) were studied to see how their insulin levels and inflammation markers changed after switching to a low-fat diet. Before the diet, these dogs had higher insulin levels and inflammation markers compared to those without high triglycerides. After starting the low-fat diet, some dogs showed a significant drop in insulin levels, indicating improvement. This suggests that a low-fat diet can help manage high triglyceride levels and reduce insulin resistance in these dogs.
People also search for: Miniature Schnauzer high triglycerides diet · dog insulin resistance treatment · low-fat diet for Schnauzers
Abstract
BACKGROUND: Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. OBJECTIVES: Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are affected by dietary intervention in MS with HTGL. ANIMALS: Seventy MS with HTGL and 79 MS without HTGL. In addition, 15 MS with HTGL were placed on a low-fat diet. METHODS: Serum concentrations of triglycerides, cholesterol, calprotectin, insulin, and glucose were compared between groups. RESULTS: Serum glucose and calprotectin concentrations (shown to be higher in MS with HTGL than in MS without HTGL) were inversely correlated (ρ = -.28; P < .001). After dietary intervention, median serum insulin concentrations were 8.1 mU/L compared to 20.8 mU/L before dietary intervention (P = .06). Dogs with complete resolution of HTGL after dietary intervention (5 dogs) had significantly lower serum insulin concentrations compared to baseline (P = .03). CONCLUSION AND CLINICAL IMPORTANCE: The subclinical inflammatory phenotype in MS with HTGL appears to be associated with IR. Resolution of HTGL by dietary intervention is associated with a decrease in serum insulin concentrations. The implication of the increase in serum calprotectin concentrations after resolution of HTGL warrants further study.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35451113/