Peer-reviewed veterinary case report
Blood pressure and protein in urine in dogs with pituitary or adrenal
By Lien, Yu-Hsin et al.·Published in Acta veterinaria Scandinavica·2010·Azu Clinic for Animals·View original on PubMed →
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Original publication title: Associations among systemic blood pressure, microalbuminuria and albuminuria in dogs affected with pituitary- and adrenal-dependent hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A study found that dogs with adrenal-dependent hyperadrenocorticism (ADH) often had higher blood pressure and more protein in their urine (albuminuria) compared to healthy dogs. While both types of hyperadrenocorticism (ADH and pituitary-dependent hyperadrenocorticism, or PDH) showed some differences in blood pressure and urine protein levels, the presence of protein in the urine wasn't linked to blood pressure levels. This means that while dogs with ADH are more likely to have high blood pressure and protein in their urine, these two issues don't necessarily affect each other. If your dog has been diagnosed with hyperadrenocorticism, it's important to monitor these conditions with your vet.
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Abstract
BACKGROUND: Hypertension and proteinuria are medical complications associated with the multisystemic effects of long-term hypercortisolism in dogs with hyperadrenocorticism (HAC). METHODS: This study investigated the relationships among adrenocorticotropic hormone (ACTH)-stimulation test results, systemic blood pressure, and microalbuminuria in clinically-healthy dogs (n = 100), in dogs affected with naturally occurring pituitary-dependent (PDH; n = 40), or adrenal-dependent hyperadrenocorticism (ADH; n = 30). RESULTS: Mean systemic blood pressure was similar between clinically healthy dogs and dogs with HAC (p = 0.803). However the incidence of hypertension was highest in dogs with ADH (p = 0.017), followed by dogs with PDH, with the lowest levels in clinically healthy dogs (p = 0.019). Presence of microalbuminuria and albuminuria in clinically healthy dogs and dogs affected with HAC was significantly different (p < 0.001); incidences of albuminuria followed the same pattern of hypertension; highest incidence in dogs with ADH, and lowest level in clinically healthy dogs; but microalbuminuria showed a different pattern: clinically healthy dogs had highest incidences and dogs with ADH had lowest incidence. The presence of albuminuria was not associated with blood pressure values, regardless of whether dogs were clinically healthy or affected with ADH or PDH (p = 0.306). CONCLUSIONS: Higher incidence of hypertension and albuminuria, not microalbuminuria was seen in dogs affected with HAC compared to clinically healthy dogs; incidence of hypertension and albuminuria was significantly higher in dogs affected with ADH compared to PDH. However, presence of albuminuria was not correlated with systemic blood pressure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21070672/