Peer-reviewed veterinary case report
Astaxanthin improves mitochondrial function in aging healthy dogs
By Park, J S et al.·Published in Journal of animal science·2013·Washington State University, United States·View original on PubMed →
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Original publication title: Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs.
- Species:
- dog
Plain-English summary
A group of healthy Beagle dogs, both young and older, were given a daily supplement of astaxanthin for 16 weeks to see if it could help improve their energy production at the cellular level. The results showed that both age groups had better mitochondrial function, which means their cells were producing energy more effectively. The older dogs particularly benefited, showing improvements in energy production and reduced oxidative damage. This suggests that adding astaxanthin to a dog's diet could be a helpful way to support their overall health as they age.
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Abstract
Young (2.97±0.01 yr; 8.16±0.15 kg BW) and geriatric (10.71±0.01 yr; 9.46±0.18 kg BW) healthy female Beagle dogs (n=14/age group) were fed 0 or 20 mg astaxanthin daily for 16 wk to examine modulation of mitochondrial function. Fasted blood was sampled on wk 0, 8, and 16. Mitochondria membrane permeability, ATP production, cytochrome c oxidase/reductase, and number were assessed in leukocytes whereas astaxanthin uptake, glutathione, superoxide dismutase, nitric oxide, 8-hydroxy-2'-deoxyguanosine, 8-isoprostane, and protein carbonyl were measured in plasma. Aging increased (P<0.05) complex III cytochrome c oxidoreductase but decreased (P<0.05) 8-hydroxy-2'-deoxyguanosine and protein carbonyl. Mitochondrial function improved in both young and geriatric dogs by increasing (P<0.05) ATP production, mitochondria mass, and cytochrome c oxidoreductase activity, especially in geriatric dogs compared with young dogs. Astaxanthin feeding also increased (P<0.05) the reduced glutathione to oxidized glutathione ratio in young dogs and decreased (P<0.05) nitric oxide in both young and geriatric dogs. Dietary astaxanthin improved mitochondrial function in blood leukocytes, most likely by alleviating oxidative damage to cellular DNA and protein.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23100599/