Peer-reviewed veterinary case report
Astaxanthin boosts immune response in young female cats
By Park, Jean Soon et al.Ā·Published in Veterinary immunology and immunopathologyĀ·2011Ā·School of Food Science, United StatesĀ·View original on PubMed ā
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Original publication title: Astaxanthin stimulates cell-mediated and humoral immune responses in cats.
- Species:
- cat
Plain-English summary
A group of young female domestic shorthair cats was given different amounts of astaxanthin, a natural antioxidant, to see how it affected their immune systems. After 12 weeks, the cats that received astaxanthin showed improved immune responses, including better reactions to vaccines and increased levels of certain immune cells and antibodies in their blood. This suggests that adding astaxanthin to a cat's diet could help boost their immune function. If you're considering dietary supplements for your cat, astaxanthin might be worth discussing with your veterinarian.
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Abstract
Astaxanthin is a potent antioxidant carotenoid and may play a role in modulating immune response in cats. Blood was taken from female domestic shorthair cats (8-9 mo old; 3.2 ± 0.04 kg body weight) fed 0, 1, 5 or 10mg astaxanthin daily for 12 wk to assess peripheral blood mononuclear cell (PBMC) proliferation response, leukocyte subpopulations, natural killer (NK) cell cytotoxic activity, and plasma IgG and IgM concentration. Cutaneous delayed-type hypersensitivity (DTH) response against concanavalin A and an attenuated polyvalent vaccine was assessed on wk 8 (prior to vaccination) and 12 (post-vaccination). There was a dose-related increase in plasma astaxanthin concentrations, with maximum concentrations observed on wk 12. Dietary astaxanthin enhanced DTH response to both the specific (vaccine) and nonspecific (concanavalin A) antigens. In addition, cats fed astaxanthin had heightened PBMC proliferation and NK cell cytotoxic activity. The population of CD3(+) total T and CD4(+) T helper cells were also higher in astaxanthin-fed cats; however, no treatment difference was found with the CD8(+) T cytotoxic and MHC II(+) activated lymphocyte cell populations. Dietary astaxanthin increased concentrations of plasma IgG and IgM. Therefore, dietary astaxanthin heightened cell-mediated and humoral immune responses in cats.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21930306/