Peer-reviewed veterinary case report
Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility.
- Journal:
- The Journal of cell biology
- Year:
- 2016
- Authors:
- Henneberger, Christian & Steinhäuser, Christian
- Affiliation:
- Institute of Cellular Neurosciences · Germany
- Species:
- rodent
Abstract
Astrocytes have been implicated in epilepsy development, but their contribution is under debate. In this issue, Shen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605046) demonstrate that early postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote excitatory synaptogenesis, thereby increasing seizure susceptibility in young and adult mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27881712/