Peer-reviewed veterinary case report
Metoprolol works better than atenolol for heart failure in dogs
By Zacà, Valerio et al.·Published in Cardiology·2009·Department of Medicine, United States·View original on PubMed →
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Original publication title: Atenolol is inferior to metoprolol in improving left ventricular function and preventing ventricular remodeling in dogs with heart failure.
- Species:
- dog
Plain-English summary
A group of dogs with heart failure were treated with either atenolol or metoprolol to see which medication worked better for improving heart function. After three months, the dogs on metoprolol showed significant improvements in heart function compared to those on atenolol, which only maintained their condition without much improvement. The dogs on metoprolol had better heart efficiency and less heart enlargement. This suggests that metoprolol is a more effective treatment for dogs with heart failure than atenolol.
People also search for: dog heart failure treatment · atenolol vs metoprolol for dogs · improving dog heart function
Abstract
OBJECTIVES: beta-Blockers are standard therapy for patients with heart failure (HF). This study compared the effects of chronic monotherapy with 2 different beta(1)-selective adrenoceptor blockers, namely atenolol and metoprolol succinate, on left ventricular (LV) function and remodeling in dogs with coronary microembolization-induced HF [LV ejection fraction (EF) 30-40%]. METHODS: Twenty HF dogs were randomized to 3 months of therapy with atenolol (50 mg once daily, n = 6), metoprolol succinate (100 mg, once daily, n = 7) or to no therapy (control, n = 7). LV EF and volumes were measured before initiating therapy and after 3 months of therapy. The change (Delta) in EF and volumes between measurements before and after therapy was calculated and compared among study groups. RESULTS: In controls, EF decreased and end-systolic volume increased. Atenolol prevented the decrease in EF and the increase in ESV. In contrast, metoprolol succinate significantly increased EF and decreased end-systolic volume. DeltaEF was significantly higher and Deltaend-systolic volume significantly lower in metoprolol succinate-treated dogs compared to atenolol-treated dogs (EF: 6.0 +/- 0.86% vs. 0.8 +/- 0.85%, p < 0.05; end-systolic volume: -4.3 +/- 0.81 ml vs. -1 +/- 0.52 ml, p <0.05). CONCLUSIONS: In HF dogs, chronic therapy with atenolol does not elicit the same LV function and remodeling benefits as those achieved with metoprolol succinate.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18832825/