Peer-reviewed veterinary case report
Atopic dermatitis linked to a specific gene region in West Highland
By Roque, Joana B et al.·Published in Immunogenetics·2012·School of Veterinary Science, Australia·View original on PubMed →
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Original publication title: Atopic dermatitis in West Highland white terriers is associated with a 1.3-Mb region on CFA 17.
- Species:
- dog
Plain-English summary
A group of West Highland white terriers with atopic dermatitis (a common allergic skin condition) was studied to understand its genetic causes. Researchers found a specific area on chromosome 17 that seems to be linked to this skin problem in these dogs. This suggests that atopic dermatitis may be inherited in Westies, and certain genes in this region could play a role in the disease. While the study didn't provide treatment details, knowing the genetic link can help veterinarians better manage and treat skin issues in affected dogs.
People also search for: West Highland white terrier skin problems · dog atopic dermatitis treatment · allergic skin disease in dogs
Abstract
Canine atopic dermatitis (AD) is an allergic inflammatory skin disease that shares similarities with AD in humans. Canine AD is likely to be an inherited disease in dogs and is common in West Highland white terriers (WHWTs). We performed a genome-wide association study using the Affymetrix Canine SNP V2 array consisting of over 42,800 single nucleotide polymorphisms, on 35 atopic and 25 non-atopic WHWTs. A gene-dropping simulation method, using SIB-PAIR, identified a projected 1.3 Mb area of association (genome-wide P = 6 × 10(-5) to P = 7 × 10(-4)) on CFA 17. Nineteen genes on CFA 17, including 1 potential candidate gene (PTPN22), were located less than 0.5 Mb from the interval of association identified on the genome-wide association analysis. Four haplotypes within this locus were differently distributed between cases and controls in this population of dogs. These findings suggest that a major locus for canine AD in WHWTs may be located on, or in close proximity to an area on CFA 17.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21989516/