Peer-reviewed veterinary case report
How new JAK-1 inhibitor helps dogs with atopic itch
By Olivry, Thierry & Bäumer, Wolfgang·Published in Handbook of experimental pharmacology·2015·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Atopic itch in dogs: pharmacology and modeling.
- Species:
- dog
Plain-English summary
Many dogs suffer from itchy skin, often due to a condition called atopic dermatitis, which can make them uncomfortable and restless. Treatments for this itch typically include topical or oral steroids and a medication called cyclosporine, which helps reduce the itching. A new treatment option, a Janus kinase (JAK)-1 inhibitor, has been shown to work quickly to relieve itching in dogs with allergies. While antihistamines can sometimes help, they are not always effective for every dog. With the right treatment, many dogs can find relief from their itching and improve their quality of life.
People also search for: dog itching treatment · atopic dermatitis in dogs · JAK inhibitor for dog allergies · why is my dog scratching · effective treatments for dog skin problems
Abstract
Itch is the most common clinical problem seen in dogs with skin diseases. Although an etiological classification of canine pruritus does not yet exist, most causes would likely fall into the IFSI class I (dermatological) itch. One of the most common causes of canine itch is that associated with atopic dermatitis, and there is randomized controlled trial grade evidence of the efficacy of several antipruritic interventions. At this time, the mainstay of treatment of canine atopic itch relies principally on the use of topical and/or oral glucocorticoids and oral cyclosporine. Type 1 receptor antihistamines are notorious in their inconsistency in reducing pruritus in atopic dogs. A new Janus kinase (JAK)-1 inhibitor has recently been approved for treatment of allergic itch in dogs, and its onset of efficacy is remarkably fast. Modeling itch in dogs can be achieved by allergen sensitization (fleas, house dust mites), and challenges that elicit pruritic manifestation can be used for mechanistic studies as well as for testing of novel anti-itch modalities.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25861789/