Peer-reviewed veterinary case report
Atopy patch test reactions to house dust mites in high-IgE beagles
By Marsella, Rosanna et al.·Published in Veterinary dermatology·2005·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Atopy patch test reactions in high-IgE beagles to different sources and concentrations of house dust mites.
- Species:
- dog
Plain-English summary
A group of six beagles with high levels of IgE (a type of antibody linked to allergies) were tested for reactions to different types and strengths of house dust mites. The dogs were given patches with various concentrations of dust mites and observed for signs of skin irritation, such as redness and bumps, over several days. The results showed that the patches with a concentration of 100 mg/mL of Greer house dust mites caused the most significant reactions, suggesting it's the best option for allergy testing in dogs. No reactions were seen with the saline control, indicating that the testing was effective.
People also search for: beagle skin allergy test · dog itching house dust mites · atopy patch test for dogs
Abstract
Protocols for atopy patch testing (APT) were evaluated on six high-IgE dogs sensitized to house dust mites (HDM) using various concentrations and sources of HDM. Two sources of HDM were compared: Heska slurry and four concentrations of Greer HDM. Saline was used as a negative control. Patches were removed after 48 h and the sites evaluated at 0, 6, 24, 48, 72 and 96 h for erythema, macules, papules and pustules. Each sign was scored from 0 to 3 (0 = absent and 3 = severe). Total score was used for analysis. Mean total scores significantly increased for both Greer and Heska HDMs from 6 h, peaking at 48 h for G100 (100 mg mL(-1)), G300 and G668, and at 72 h for Heska and G31.25. Across all times, Heska HDM scores were significantly higher than those of G31.25 with the largest difference at 96 h. Heska scores, however, were significantly lower than those of other Greer concentrations (G100, G300 and G668) particularly at 96 h. No reactions were noted at saline sites. It is concluded that Greer-HDM at 100 mg mL(-1) is the most suitable concentration for APT in dogs because it induces reactions comparable if not higher than more concentrated HDM preparations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16238810/