Peer-reviewed veterinary case report
Using infrared light to screen for cancer in dogs from blood samples
By Macotpet, Arayaporn et al.·Published in Journal of veterinary science·2020·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Attenuated total reflection Fourier transform infrared as a primary screening method for cancer in canine serum.
- Species:
- dog
Plain-English summary
A group of dogs with cancer had their blood tested using a new method called ATR-FTIR, which can help identify cancer without needing special sample preparation. The study found that dogs with cancer had lower red blood cell counts, hemoglobin levels, and white blood cell counts compared to healthy dogs. The ATR-FTIR technique showed clear differences in the blood samples, suggesting it could be a useful tool for screening dogs for cancer. This could help veterinarians detect cancer earlier in dogs, potentially leading to better treatment outcomes.
People also search for: dog cancer screening blood test · symptoms of cancer in dogs · how to detect cancer in dogs
Abstract
Cancer is a major cause of death in dogs worldwide, and the incidence of cancer in dogs is increasing. The attenuated total reflection Fourier transform infrared spectroscopic (ATR-FTIR) technique is a powerful tool for the diagnosis of several diseases. This method enables samples to be examined directly without pre-preparation. In this study, we evaluated the diagnostic value of ATR-FTIR for the detection of cancer in dogs. Cancer-bearing dogs (n = 30) diagnosed by pathologists and clinically healthy dogs (n = 40) were enrolled in this study. Peripheral blood was collected for clinicopathological diagnosis. ATR-FTIR spectra were acquired, and principal component analysis was performed on the full wave number spectra (4,000-650 cm). The leave-one-out cross validation technique and partial least squares regression analysis were used to predict normal and cancer spectra. Red blood cell counts, hemoglobin levels and white blood cell counts were significantly lower in cancer-bearing dogs than in clinically healthy dogs (< 0.01,< 0.01 and= 0.03, respectively). ATR-FTIR spectra showed significant differences between the clinically healthy and cancer-bearing groups. This finding demonstrates that ATR-FTIR can be applied as a screening technique to distinguish between cancer-bearing dogs and healthy dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31940695/