Attenuation ofInfection by.

Abstract

infection (CDI) is a bacterial infection of the colon that can cause diarrhea and colitis. The use of antimicrobials disrupts the intestinal microbiota, weakening colonization resistance and creating an environment in whichcan establish infection. It is, therefore, necessary to identify specific bacteria that are helpful for the recovery of the intestinal microbiota in individuals with CDI. Previous studies have identified several strains that showed a negative correlation with. Among these strains,DSM 15053, which possesses theoperon similar to, was selected. To test this hypothesis, we utilized a CDI mouse model and evaluated the inhibitory effect ofDSM 15053. Furthermore, to gain insights into the underlying mechanisms, we performed gut microbiota analysis. Contrary to our expectations,DSM 15053 did not significantly produce SBAs. Interestingly, however, microbial diversity and richness were significantly higher in theDSM 15053-treated group compared with the PBS control group. In addition, we observed a higher abundance of the genera,, andin theDSM 15053 group. Moreover, metagenomic and metabolomic analyses revealed thatDSM 15053 mitigates CDI through a mechanism distinct from that ofKCTC 5591, which primarily functions as a regulator of bile acid metabolism.