Peer-reviewed veterinary case report
Unusual eye lesions in Siberian Huskies with glaucoma
By Park, Shin Ae et al.·Published in BMC veterinary research·2022·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Atypical chorioretinal lesions in Siberian Husky dogs with primary angle-closure glaucoma: a case series.
- Species:
- dog
Plain-English summary
Three Siberian Huskies, aged 3, 4, and 11 months, were brought in with unusual eye problems, including multiple light-colored spots on their retinas and signs of primary angle-closure glaucoma (PACG), which can lead to vision loss. After thorough eye examinations and tests, veterinarians found that two of the dogs had significant retinal damage and changes in their eye structure. Unfortunately, the tests confirmed that the eye issues were linked to the glaucoma, which caused severe blood flow problems in the eyes. While the exact cause of the retinal lesions remains unclear, the dogs were diagnosed with serious eye conditions that require ongoing monitoring and care.
People also search for: Siberian Husky eye problems · primary angle-closure glaucoma in dogs · retinal lesions in dogs
Abstract
BACKGROUND: A number of etiologies for different canine chorioretinal lesions have been proved or suggested but some fundic lesions remain unclear in terms of an etiologic diagnosis, treatment options and prognosis. The purpose of this case series is to describe atypical chorioretinal lesions observed in dogs with primary angle-closure glaucoma (PACG). CASE PRESENTATION: Two spayed-female Siberian Huskies (3- and 4-year-old) and one Siberian Husky/Australian Shepherd mixed breed dog (11-month-old) that had multifocal depigmented retinal lesions and PACG were included. PROCEDURES: Ophthalmic examination, gross, and histopathologic examination findings are described. One of the dogs underwent further clinical diagnostics. Advanced clinical diagnostics on the fellow, presumed to be non-glaucomatous eye of a dog revealed: pectinate ligament dysplasia by gonioscopy, retinal thinning in the depigmented area and wedge shaped retinal thinning with delayed choroidal vascular perfusion by optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein and indocyanine green angiography. Quantifiable maze testing for the same eye revealed mild nyctalopia but the full-field electroretinogram showed no generalized decrease of retinal function. Genetic testing for mutations within the retinitis pigmentosa GTPase regulator gene causing X-linked progressive retinal atrophy in Siberian Huskies was negative. Histopathologic evaluations on enucleated eyes in two dogs confirmed goniodysgenesis, PACG with optic nerve head cupping, and diffuse inner retinal atrophy. In addition, segmental profound retinal atrophy, loss of retinal pigment epithelium, and adhesion of the retina to Bruch's membrane was observed and coincided with multifocal depigmented lesions noted on fundic examination. CONCLUSIONS: To our knowledge, this is the first case series with clinical and histopathologic data of chorioretinal lesions, most likely caused by severely impaired choroidal perfusion. Further studies are warranted to elucidate the etiology and pathophysiology, including its possible association with PACG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35578341/