Peer-reviewed veterinary case report
Dog with unusual Cushing's signs treated successfully with trilostane
By Hoffrogge, Stefanie et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2017·View original on PubMed →
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Original publication title: [Atypical Cushing's syndrome in a dog. A case report].
- Species:
- dog
Plain-English summary
A 12-year-old male Labrador Retriever was brought in for various health issues, and during the examination, the vet discovered signs of atypical Cushing's syndrome, including increased thirst and urination, a swollen belly, and muscle loss. Tests showed abnormal adrenal gland results, but standard tests for Cushing's were negative. After further testing, the dog was diagnosed with atypical hyperadrenocorticism and responded well to treatment with a medication called trilostane. The case highlights the challenges in diagnosing this condition, especially with other health problems present.
People also search for: dog increased thirst and urination · atypical Cushing's syndrome in dogs · trilostane for dogs · Labrador Retriever health issues
Abstract
In a 12-year-old male Labrador Retriever, presented due to other disease symptoms, clinical signs of hyperadrenocorticism (polyuria, polydipsia, abdominal distention, muscle atrophy) were an incidental finding. Abnormal laboratory results and sonographic findings of the adrenal glands, but negative low-dose dexamethasone suppression tests with low basal cortisol concentrations, a negative andrenocorticotropic hormone (ACTH)-stimulation test and exclusion of iatrogenic hyperadrenocorticism, suggested an atypical hyperadrenocorticism (AHAC). Results of further examinations, particularly stimulation of progesterone production by ACTH (0 h value: 0.21 ng/ml; 1 h value: 4.9 ng/ml) and good response to therapy with trilostane, supported this diagnosis. However, it has to be critically considered, whether and to what extent additionally present diseases (arthroses, testicular tumour) played a role regarding the symptoms and laboratory results in this dog. This case illustrates the difficulties with the diagnosis of AHAC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28447709/