Peer-reviewed veterinary case report
Vomiting and lethargy in Cavalier King Charles Spaniel
By Clarke, Lorelei L et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2017·Department of Pathology, United States·View original on PubMed →
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Original publication title: Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog.
- Species:
- dog
Plain-English summary
A 10-year-old Cavalier King Charles Spaniel was brought in because he had been vomiting, not eating, and seemed very tired for about 10 days. The vet found some nodules in his spleen during an ultrasound, which looked like they could be cancer. Sadly, after the dog passed away, an autopsy revealed that he had a type of cancer called histiocytic sarcoma, which had spread to his lungs, spleen, and adrenal glands. This type of cancer is rare and can have unusual symptoms, making it hard to diagnose early.
People also search for: Cavalier King Charles Spaniel vomiting · dog cancer symptoms · histiocytic sarcoma treatment
Abstract
A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate. Cells stained positive for vimentin and CD18 and negative for cytokeratin, chromogranin A, CD3, CD20, MHC II, and CD11d, and hence the tumor was diagnosed as a histiocytic sarcoma. The cytologic presentation in this case is uncommon for this type of tumor, as was the clinical presentation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28381106/